Institut für Funktionelle Grenzflächen (IFG)

Selective and Reversible Binding of Thiol-Functionalized Biomolecules on Polymers Prepared via Chemical Vapor Deposition Polymerization

  • Autor:

    Ross, A. / Durmaz, H. / Cheng, K. / Deng, X. / Liu, Y. / Oh, J. / Chen, Z. / Lahann, J. (2015)

  • Quelle:

    Langmuir 31, (2015), 18,  5123-5129

  • Datum: May 12 2015


We use chemical vapor deposition polymerization to prepare a novel dibromomaleimide-functionalized polymer for selective and reversible binding of thiol-containing biomolecules on a broad range of substrates. We report the synthesis and CVD polymerization of 4-(3,4-dibromomaleimide) [2.2]paracyclophane to yield nanometer thick polymer coatings. Fourier transformed infrared spectroscopy and X-ray photoelectron spectroscopy confirmed the chemical composition of the polymer coating.

The reactivity of the polymer coating toward thiol-functionalized molecules was confirmed using fluorescent ligands.As a proof of concept, the binding and subsequent release of cysteine-modified peptides from the polymer coating were also demonstrated via sum frequency generation spectroscopy. This reactive polymer coating provides a flexible surface modification approach to selectively and reversibly bind biomolecules on a broad range of materials, which could open up new opportunities in many biomedical sensing and diagnostic applications where specific binding and release of target analytes are desired.


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