Lipase-catalyzed synthesis of glucose-6-O-hexanoate in deep eutectic solvents

  • Autor:

    Pöhnlein, M. / Ulrich, J. / Kirschhöfer, F. / Nusser, M. / Muhle-Goll, C. / Kannengiesser, B. / Brenner-Weiß, G. / Luy, B. / Liese, A. / Syldatk, C. / Hausmann, R. (2015)

  • Quelle:

    Eur J Lipid Soc Technol. 117, 2 (2015), 161-166

  • Datum: 30. Januar 2015


Enzymatic synthesis of sugar fatty acid esters in organic solvents is a well-described procedure to synthesize glycolipids. This study aims at replacing these solvents with deep eutectic solvents (DES), a group of solvents that gained more and more interest during the last years, since they can be easily produced from non-toxic resources. Enzymatic glycolipid synthesis in deep eutectic solvents was investigated, employing Candida antarctica lipase B (Novozyme 435) in various deep eutectic solvents.


A successful lipase-catalyzed synthesis of glucose fatty acid esters gave proof of this concept, while using the two deep eutectic solvents consisting of choline chloride and urea (CC : U) and choline chloride and glucose (CC : Glc). Additionally the DES consisting of choline chloride and glucose was observed to act as solvent and substrate for the synthesis at the same time.