Antibiotic resistant pathogenic bacteria and their resistance genes in bacterial biofilms
Obst, U. / Schwartz, T. / Volkmann, H. (2006)
Int. J. Art. Org. 29 (2006), 387-394
- Datum: 2006
Obst, U. / Schwartz, T. / Volkmann, H. (2006): „Antibiotic resistant pathogenic bacteria and their resistance genes in bacterial biofilms“. In: Int. J. Art. Org. 29 (2006), 387-394
Although data concerning the occurrence and spread of resistant bacteria within hospital care units are available, the fate of these bacteria in the environment and especially in the aquatic environment has barely been investigated. Once antibiotic resistant bacteria have entered the environment, a back coupling by ingestion or other possible entry into the host has to be prevented. Therefore a strategy to investigate paths of entry, accumulation and spread of resistant bacteria in environmental compartments has been developed using quantitative determination of genetic resistance determinants.
Additionally a bacterial bioassay assessed bioeffectivity thresholds of low antibiotic concentrations. This approach enables an evaluation of the potential of contaminated waters to exert a selection pressure on bacterial communities and thus promote the persistence of resistant organisms. Completed with an indicator system for the identification of sources of multiresistant bacteria a concept for monitoring and evaluation of environmental compartments with respect to their potential of antibiotic resistance dissemination is suggested.