Bachelor or Master thesis
„Development of an in vitro test system for 3rd generation CAR-T-cells“
Cellular immune therapies are gaining more and more attention. Among these are those using recombinant T-cell receptors or chimeric antigen receptors (CAR-T-cells). These tumor specific T-cells display a huge potential that has already been shown in various tumor species. The broader application of these new therapies is hampered by the high costs and the lack of appropriate in vitro test systems. Therefore, the master thesis topic will be dedicated to the development of a microcavity array-based in vitro system which will be able to determine the potency of CAR-T-cells prior to infusion into the patient. For this, a leukemic stem cell niche will be developed that allows for the longitudinal observation of CAR-T-cells in a microbioreactor system (4D-microscopy).
The thesis will be conducted in the framework of a cooperation project with the University Clinic in Heidelberg and offers the possibility of using primary material. The results of the thesis will be highly valuable since they will have a direct impact on the use of CAR-T-cells within a running CAR-T-cell study.
If you are interested in micro systems, stem cells and confocal microscopy or should you need more information, please contact:
Prof. Dr. Eric Gottwald
Email: eric gottwald∂ kit edu
Topics for theses are continuously assigned