Bioprocess development and modelling
Head of the working group Research focus
Prof. Dr.-Ing.Matthias Franzreb
Theses
The Bioprocess Development and Modelling group is concerned with the simulation-based development of novel synthesis, separation and analytical processes in biotechnology. Current focus topics are enzyme reactors and electro-biotechnological processes, the development of selective and energy-efficient separation processes for molecules, cells and particles, as well as the use of additive manufacturing processes for novel (bio)analytical systems. Process development includes rapid prototyping using various 3D printing techniques as well as the generation of an in-depth process understanding through intensive use of various modeling and simulation tools. The modeling methods used range from molecular dynamics simulation, multiphysics finite element models, to digital twins of complete bioprocesses.
Main research topics of the working group Bioprocess Development and Modelling
I Bioprocess Modeling
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The Bioprocess Modelling group is concerned with the simulation of processes and materials used in biotechnology. Besides the simulative part, experimental data are generated as training sets for algorithms for the development of digital twins of chromatography materials or filtration systems. |
| Current projects: |
| Development of digital twins for polymer-based chromatography resins |
| Intensification of dynamic crossflow filtration processes in the food industry using hybrid digital twins |
II Bioseparation and analysis
| The Bioseparation and Analytics group is concerned with the development, production and characterization of tailor-made, novel separation processes for preparative and analytical applications. Different tools are used, such as multiphysics and process simulations, additive manufacturing techniques and new adsorption materials. |
| Current projects: |
| Development of a magnetic decanter for algae separation |
| Continuous fractionation of fine particles by magnetic field controlled counter current chromatography |
| Development of a modular diagnostic system |
| Simulation-based development of a micro-SMB |
III Biocatalysis and Sensor Technology
| In the Biocatalysis and Sensor Technology group, enzymes (biocatalysts) are immobilized on carriers (magnetic particles/MOF) in order to use them in novel reactor systems. In addition, we work on the development of impedance-based sensor systems, with which the carrier material as well as its interaction with the corresponding catalyst can be investigated in more detail. |
| Current projects: |
| Magnetically assisted electrochemical fluidized bed reactor for electroenzymatic syntheses using a gas phase. |
| Impedimetric characterization of dielectric layers |
| Immobilization of enzymes in metal-organic framework compounds |
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