Chemically Orthogonal Three-Patch Microparticles
Rahmani, S. / Saha, S. / Durmaz, H. / Donini, A. / Misra, A. / Yoon, J. / Lahann, J. (2014)
Angewandte Chemie 126 (2014), 9, 2364-2370
- Date: 2014
Rahmani, S. / Saha, S. / Durmaz, H. / Donini, A. / Misra, A. / Yoon, J. / Lahann, J. (2014): „Chemically Orthogonal Three-Patch Microparticles“. In: Angewandte Chemie 126 (2014), 9, 2364-2370
Compared to two-dimensional substrates, only a few methodologies exist for the spatially controlled decoration of three-dimensional objects, such as microparticles. Combining electrohydrodynamic co-jetting with synthetic polymer chemistry, we were able to create two- and three-patch microparticles displaying chemically orthogonal anchor groups on three distinct surface patches of the same particle.
This approach takes advantage of a combination of novel chemically orthogonal polylactide-based polymers and their processing by electrohydrodynamic co-jetting to yield unprecedented multifunctional microparticles. Several micropatterned particles were fabricated displaying orthogonal click functionalities.
Specifically, we demonstrate novel two- and three-patch particles. Multi-patch particles are highly sought after for their potential to present multiple distinct ligands in a directional manner. This work clearly establishes a viable route towards orthogonal reaction strategies on multivalent micropatterned particles.