Substrate Specificity and Function of Acetylpolyamine Amidohydrolases from Pseudomonas aeruginosa

  • chair:

    Kraemer, A. / Herzer, J. / Overhage, J. / Meyer-Almes, F.-J. (2016) 

  • place:

    BMC Biochemistry, (2016), 17:4,  DOI

  • Date: März 2016


Pseudomonas aeruginosa, a Gram-negative, aerobic coccobacillus bacterium is an opportunistic human pathogen and worldwide the fourth most common cause of hospital-acquired infections which are often high mortality such as ventilator-associated pneumoniae. The polyamine metabolism of P. aeruginosa and particularly the deacetylation of acetylpolyamines has been little studied up to now. Results with other bacterial pathogens e.g., Y. pestis suggest that polyamines may be involved in the formation of biofilms or confer resistance against certain antibiotics.