Institut für Funktionelle Grenzflächen (IFG)

Easy Strategy To Protect Antimicrobial Peptides from Fast Degradation in Serum

  • Autor:

    Knappe, D. / Henklein, P. / Hoffmann, R. / Hilpert, K. (2010)

  • Quelle:

    Antimicrobial Agents and Chemotherapy 54 (2010), 9, 4003-4005

  • Datum: 2010
  • Knappe, D. / Henklein, P. / Hoffmann, R. / Hilpert, K. (2010): „Easy Strategy To Protect Antimicrobial Peptides from Fast Degradation in Serum“. In: Antimicrobial Agents and Chemotherapy 54 (2010), 9, 4003-4005

Abstract

Antimicrobial peptides are promising novel peptide leads, but their low serum stability often limits their further consideration in drug development programs. Here, we describe a generally applicable strategy to stabilize peptides against serum proteases by replacing arginine residues with α-amino-3-guanidino-propionic acid (Agp). Peptide NH2-RRWRIVVIRVRR-CONH2 was nearby totally degraded after 8 h in mouse serum, whereas the variant with Agp substituted was degraded less than 20%. The antimicrobial activity was not affected.

 

 

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