Institute of Functional Interfaces

Antibiotic resistance and bioeffectiveness of pharmaceuticals

Antibiotikaresistenz

 

 

Due to the worldwide high consumption of antibacterial agents, more and more antibiotic-resistant bacteria are appearing in our environment, where they can multiply under suitable conditions and become a problem in case of infection. Antibiotic-resistant bacteria are collected from clinical and domestic wastewater in sewage treatment plants and released into the environment via the treated wastewater. To determine the resistance situation to antibiotics in bacteria, compartments of the aquatic path of use are qualitatively and quantitatively detected clinically relevant resistance determinants (genes, mutations) in bacteria using molecular biological methods.


Multi-resistant bacteria are being specifically investigated in order to identify main entry and distribution pathways. Newly developed quantitative concepts for the determination of resistance levels allow biological risk analysis.


Die Bioeffektivität gering konzentrierter Antibiotika und anderer Biozide bei Bakterien werden in der Arbeitsgruppe über Genexpressionsanalysen erfasst. Die Expression spezifischer Resistenzmechanismen werden dabei auf mRNA Ebene quantifiziert und mit geeigneten molekularen Systemen, den sogenannten „house-keeping“ Genen, in Bezug gesetzt.