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Peptide-based SAMs that resists the Adsorption of Proteins

Peptide-based SAMs that resists the Adsorption of Proteins
chair: Chelmowski, R. / Köster, S.D. / Kerstan, A. / Prekelt, A. / Grunwald, Ch. / Winkler, T. / Metzler-Nolte, N. / Terfort, A. / Wöll, Ch. (2008)

place:

J. Am. Chem. Soc. 130 (2008), 45, 14952-14953

Date: 2008

Chelmowski, R. / Köster, S.D. / Kerstan, A. / Prekelt, A. / Grunwald, Ch. / Winkler, T. / Metzler-Nolte, N. / Terfort, A. / Wöll, Ch. (2008): "Peptide-based SAMs that resists the Adsorption of Proteins". In: J. Am. Chem. Soc. 130 (2008), 45, 14952-14953

Abstract

In this paper we present a modular approach for the fabrication of surfaces to characterize protein-protein interactions. The approach is based on azido peptides with an optimized sequence which are then thiol-functionalized using an alkynyl thiol and "click" chemistry. From these peptide thiols we fabricated SAMs on gold to evaluate the protein resistance, using surface plasmon resonance spectroscopy, toward streptavidin, bovin serum albumin (BSA), and fibronectin.


 

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