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Cationic Heterooligopeptides by Ficain-catalyzed Co-oligomerization of Lysine and Methionine Ethylesters

Cationic Heterooligopeptides by Ficain-catalyzed Co-oligomerization of Lysine and Methionine Ethylesters
chair:

Andre, M. / Kuehl, B. / Brenner-Weiss, G. / Syldatk, C. / Rudat, J. (2014)

place:

Journal of Peptide Science 20 (2014), 8, 625–629

Date: 2014

Andre, M. / Kuehl, B. / Brenner-Weiss, G. / Syldatk, C. / Rudat, J. (2014): „Cationic Heterooligopeptides by Ficain-catalyzed Co-oligomerization of Lysine and Methionine Ethylesters“. In: Journal of Peptide Science 20 (2014), 8, 625–629

Abstract

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Oligopeptides are of high importance for various industrial applications, e.g. cosmetical or medical. Homooligomerizations and co-oligomerizations with anionic amino acid esters are well described but a successful synthesis of cationic heterooligopeptides has been missing so far. The present study reports the ficain-catalyzed heterooligomerizations of LysOEt with MetOEt, leading to cationic heterooligopeptides with a yield up to 49.5% (w/w). MALDI-ToF/ToF-MS analyses proved successful syntheses of cationic heterooligopeptides with a DP between 7 and 10 amino acid residues, with the enzyme exhibiting a clear preference for methionine