Chemical Biology of Precision Biomaterials Publications

The Department of Chemical Biology and Precision Biomaterials ranges from organ-targeted drug delivery to autonomous high-throughput biomaterials development for 3D tissue printing and organoids reconstruction in personalized medicine.

 

Selected Publications

Molecular models and a cellular structure illustration with the Journal of the American Chemical Society logo.
Photoswitchable Fluorescence of Peptide-Based Hemipiperazines Inside of Living Cells

Göckler, R.; Rösch, A.; Kirchner, S.; Elbuga-Ilica, R.; Seliwjorstow, A.; Fuhr, O.; Schepers, U.; Pianowski, Z. J Am Chem Soc. 2025, 147, 26652-26662

 

This study introduces a water-based synthesis of GelNB, which with GelS forms the fast-curing GelNB/GelS hydrogel. Compared to GelMA, it requires less photoinitiator, cures in seconds, and shows higher homogeneity and biocompatibility.

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Diagram illustrating cancer cell transmigration through membrane pores via integrin and DNA origami.
A Versatile Microfluidic Platform for Extravasation Studies Based on DNA Origami-Cell Interactions

García-Chamé, M; Wadhwani, P.; Pfeifer, J.; Schepers, U.; Niemeyer, C. M.; Domínguez, C. M.; Angew Chem Int Ed Engl. 2024, 63, e202318805

 

The vasquip, a microfluidic bloss vessel system, which was developed by the Schepers group was treated with DNA origami nanostructures that mimics endothelial barriers to study cancer cell extravasation. The device simulates physiological flow conditions and allows direct visualization of cell transmigration through microchannel pores using 3D confocal imaging.

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Diagram illustrating the mixing of cells with GelNB and GelS polymers to form a 3D bioprinted structure.
Tuning Superfast Curing Thiol-Norbornene-Functionalized Gelatin Hydrogels for 3D Bioprinting

Göckler, T.; Haase, S.; Kempter, X.; Pfister, R.; Maciel, B. R.; Grimm, A.; Molitor, T.; Willenbacher, N.; Schepers, U. Adv Healthc Mater. 2021, 10, e2100206

 

This study introduces a water-based synthesis of GelNB, which with GelS forms the fast-curing GelNB/GelS hydrogel. Compared to GelMA, it requires less photoinitiator, cures in seconds, and shows higher homogeneity and biocompatibility.

Read full article

All Publications


2025
  1. Photoswitchable Fluorescence of Peptide-Based Hemipiperazines Inside of Living Cells
    Gödtel, P.; Rösch, A.; Kirchner, S.; Elbuga-Ilica, R.; Seliwjorstow, A.; Fuhr, O.; Schepers, U.; Pianowski, Z.
    2025. Journal of the American Chemical Society, 147 (30), 26652–26662. doi:10.1021/jacs.5c07013
2024
  1. Modulating the photolysis of aryl azides in a supramolecular host to develop photoactivatable fluorophores
    Qiu, X.; Pohl, E.; Jung, A.; Cai, Q.; Su, H.; Fuhr, O.; Schepers, U.; Bräse, S.
    2024. Chemical Communications, 60 (88), 12856–12859. doi:10.1039/d4cc03907f
  2. A simple method to modulate the selectivity of aryl azide photolysis using cucurbit[8]uril
    Qiu, X.; Cai, Q.; Pohl, E.; Jung, A.; Su, H.; Fuhr, O.; Schepers, U.; Bräse, S.
    2024. Chemical Communications, 60 (88), 12852–12855. doi:10.1039/d4cc04209c
  3. A Versatile Microfluidic Platform for Extravasation Studies Based on DNA Origami—Cell Interactions
    García-Chamé, M.; Wadhwani, P.; Pfeifer, J.; Schepers, U.; Niemeyer, C. M.; Domínguez, C. M.
    2024. Angewandte Chemie International Edition, 63 (28), Art.-Nr.: e202318805. doi:10.1002/anie.202318805
  4. Block Polyelectrolyte Additives That Modulate the Viscoelasticity and Enhance the Printability of Gelatin Inks at Physiological Temperatures
    Göckler, T.; Albreiki, F.; Li, D.; Grimm, A.; Mecklenburg, F.; Urueña, J. M.; Schepers, U.; Srivastava, S.
    2024. ACS Applied Polymer Materials, 6 (5), 2427–2441. doi:10.1021/acsapm.3c01085
  5. Modulating and Accelerating Photolysis of Photoactivatable [2.2]Paracyclophane Aryl Azide in Supramolecular Host for Bioimaging
    Qiu, X.; Pohl, E.; Cai, Q.; Seibert, J.; Li, Y.; Leopold, S.; Fuhr, O.; Meier, M. A. R.; Schepers, U.; Bräse, S.
    2024. Advanced Functional Materials, Art.-Nr.: 2401938. doi:10.1002/adfm.202401938
  6. Cocktail of lipophilic and hydrophilic chemotherapeutics in high-load core@shell nanocarriers to treat pancreatic tumours
    Rudolph, D.; Ischyropoulou, M.; Pfeifer, J.; Napp, J.; Schepers, U.; Alves, F.; Feldmann, C.
    2024. Nanoscale Advances, 6 (3), 973–984. doi:10.1039/D3NA00720K
  7. Azide Thermolysis Frameworks: Self‐inflating, Porous, and Lightweight Materials
    Brückel, J.; Matt, Y.; Schmidt, L.; Mattern, C. M.; Schepers, U.; Leopold, S.; Calkovsky, M.; Gerthsen, D.; Bräse, S.
    2024. ChemNanoMat, 10 (2), Art.-Nr.: e202300222. doi:10.1002/cnma.202300222
  8. Modulating Aryl Azide Photolysis: Synthesis of a Room‐Temperature Phosphorescent Carboline in Cucurbit[7]uril Host
    Qiu, X.; Wang, Y.; Leopold, S.; Lebedkin, S.; Schepers, U.; Kappes, M. M.; Biedermann, F.; Bräse, S.
    2024. Small, 20 (16), Art.Nr.: 2307318. doi:10.1002/smll.202307318
2023
  1. Printed Electronic Devices and Systems for Interfacing with Single Cells up to Organoids
    Saghafi, M. K.; Vasantham, S. K.; Hussain, N.; Mathew, G.; Colombo, F.; Schamberger, B.; Pohl, E.; Marques, G. C.; Breitung, B.; Tanaka, M.; Bastmeyer, M.; Selhuber-Unkel, C.; Schepers, U.; Hirtz, M.; Aghassi-Hagmann, J.
    2023. Advanced Functional Materials, 33 (51), Art.-Nr.: 2308613. doi:10.1002/adfm.202308613
  2. Targeted micro-heterogeneity in bioinks allows for 3D printing of complex constructs with improved resolution and cell viability
    Maciel, B. R.; Grimm, A.; Oelschlaeger, C.; Schepers, U.; Willenbacher, N.
    2023. Biofabrication, 15 (4), Art.-Nr.: 045013. doi:10.1088/1758-5090/acee22
  3. Bioconjugation in Materials Science
    Bednarek, C.; Schepers, U.; Thomas, F.; Bräse, S.
    2023. Advanced Functional Materials, 34 (20), Art.-Nr.: 2303613. doi:10.1002/adfm.202303613
  4. Theranostic inorganic–organic hybrid nanoparticles with a cocktail of chemotherapeutic and cytostatic drugs
    Khorenko, M.; Pfeifer, J.; Napp, J.; Meschkov, A.; Alves, F.; Schepers, U.; Feldmann, C.
    2023. Journal of Materials Chemistry B, 11 (16), 3635–3649. doi:10.1039/D3TB00226H
2022
  1. Polyelectrolyte Complex-Covalent Interpenetrating Polymer Network Hydrogels
    Li, D.; Göckler, T.; Schepers, U.; Srivastava, S.
    2022. Macromolecules, 55 (11), 4481–4491. doi:10.1021/acs.macromol.2c00590
  2. Polyelectrolyte Complex-Covalent Interpenetrating Polymer Network Hydrogels
    Li, D.; Göckler, T.; Schepers, U.; Srivastava, S.
    2022. American Chemical Society (ACS). doi:10.26434/chemrxiv-2022-b73xh
  3. The jasmonate biosynthesis Gene OsOPR7 can mitigate salinity induced mitochondrial oxidative stress
    Asfaw, K. G.; Liu, Q.; Eghbalian, R.; Purper, S.; Akaberi, S.; Dhakarey, R.; Münch, S. W.; Wehl, I.; Bräse, S.; Eiche, E.; Hause, B.; Bogeski, I.; Schepers, U.; Riemann, M.; Nick, P.
    2022. Plant science, 316, Article no: 111156. doi:10.1016/j.plantsci.2021.111156
  4. Novel tetrameric cell penetrating antimicrobial peptoids effective against mycobacteria and drug-resistant Staphylococcus aureus
    Fleck, B. S.; Mukherjee, D.; Tram, N. D. T.; Ee, P. L. R.; Schepers, U.
    2022. Frontiers in bioscience (Landmark edition), 27 (2), Art.-Nr.: 64. doi:10.31083/j.fbl2702064
  5. Evaluation of a Novel Thiol–Norbornene-Functionalized Gelatin Hydrogel for Bioprinting of Mesenchymal Stem Cells
    Burchak, V.; Koch, F.; Siebler, L.; Haase, S.; Horner, V. K.; Kempter, X.; Stark, G. B.; Schepers, U.; Grimm, A.; Zimmermann, S.; Koltay, P.; Strassburg, S.; Finkenzeller, G.; Simunovic, F.; Lampert, F.
    2022. International Journal of Molecular Sciences, 23 (14), Artkl.Nr.: 7939. doi:10.3390/ijms23147939
2021
  1. Bio-instructive materials on-demand-combinatorial chemistry of peptoids, foldamers, and beyond
    Herlan, C. N.; Feser, D.; Schepers, U.; Bräse, S.
    2021. Chemical Communications, 57 (85), 11131–11152. doi:10.1039/d1cc04237h
  2. Designing Inherently Photodegradable Cell‐Adhesive Hydrogels for 3D Cell Culture
    Rosenfeld, A.; Göckler, T.; Kuzina, M.; Reischl, M.; Schepers, U.; Levkin, P. A.
    2021. Advanced healthcare materials, 10 (16), Art.Nr. 2100632. doi:10.1002/adhm.202100632
  3. Cyclic Peptoid-Peptide Hybrids as Versatile Molecular Transporters
    Herlan, C. N.; Meschkov, A.; Schepers, U.; Bräse, S.
    2021. Frontiers in Chemistry, 9, Art. Nr.: 696957. doi:10.3389/fchem.2021.696957
  4. Total synthesis of decarboxyaltenusin
    Warmuth, L.; Weiß, A.; Reinhardt, M.; Meschkov, A.; Schepers, U.; Podlech, J.
    2021. Beilstein Journal of Organic Chemistry, 17, 224–228. doi:10.3762/BJOC.17.22
  5. Intriguing Heteroleptic Zn bis(dipyrrinato) Emitters in the Far-Red Region With Large Pseudo-Stokes Shift for Bioimaging
    Tabone, R.; Feser, D.; Lemma, E. D.; Schepers, U.; Bizzarri, C.
    2021. Frontiers in Chemistry, 9, 754420. doi:10.3389/fchem.2021.754420
  6. Tuning Superfast Curing Thiol-Norbornene-Functionalized Gelatin Hydrogels for 3D Bioprinting
    Göckler, T.; Haase, S.; Kempter, X.; Pfister, R.; Maciel, B. R.; Grimm, A.; Molitor, T.; Willenbacher, N.; Schepers, U.
    2021. Advanced Healthcare Materials, 10 (14), Art.-Nr. 2100206. doi:10.1002/adhm.202100206
  7. Highly NIR-emitting ytterbium complexes containing 2-(tosylaminobenzylidene)-N-benzoylhydrazone anions: structure in solution and use for bioimaging
    Kovalenko, A. D.; Pavlov, A. A.; Ustinovich, I. D.; Kalyakina, A. S.; Goloveshkin, A. S.; Marciniak, Ł.; Lepnev, L. S.; Burlov, A. S.; Schepers, U.; Bräse, S.; Utochnikova, V. V.
    2021. Dalton Transactions, 50 (11), 3786–3791. doi:10.1039/d0dt03913f
2020
  1. A mitochondria-targeted coenzyme Q peptoid induces superoxide dismutase and alleviates salinity stress in plant cells
    Asfaw, K. G.; Liu, Q.; Xu, X.; Manz, C.; Purper, S.; Eghbalian, R.; Münch, S. W.; Wehl, I.; Bräse, S.; Eiche, E.; Hause, B.; Bogeski, I.; Schepers, U.; Riemann, M.; Nick, P.
    2020. Scientific reports, 10, Article number:11563. doi:10.1038/s41598-020-68491-4
  2. The Staudinger Ligation
    Bednarek, C.; Wehl, I.; Jung, N.; Schepers, U.; Bräse, S.
    2020. Chemical reviews, 120 (10), 4301–4354. doi:10.1021/acs.chemrev.9b00665
2019
  1. Author Correction: A Peptoid Delivers CoQ-derivative to Plant Mitochondria via Endocytosis
    Asfaw, K. G.; Liu, Q.; Maisch, J.; Münch, S. W.; Wehl, I.; Bräse, S.; Bogeski, I.; Schepers, U.; Nick, P.
    2019. Scientific reports, 9 (1), Art.Nr.: 18832. doi:10.1038/s41598-019-54996-0
  2. Anti-Tumor Activity of Doxorubicin-loaded Boehmite Nanocontainers
    Seidl, C.; Simonato, S.; Zittel, E.; Schepers, U.; Feldmann, C.
    2019. Zeitschrift für anorganische und allgemeine Chemie, 645 (24), 1372–1378. doi:10.1002/zaac.201900211
  3. A Peptoid Delivers CoQ-derivative to Plant Mitochondria via Endocytosis
    Asfaw, K. G.; Liu, Q.; Maisch, J.; Münch, S. W.; Wehl, I.; Bräse, S.; Bogeski, I.; Schepers, U.; Nick, P.
    2019. Scientific reports, 9 (1), Art.Nr.: 9839. doi:10.1038/s41598-019-46182-z
  4. Synthesis, Characterization, and Biological Properties of Steroidal Ruthenium(II) and Iridium(III) Complexes Based on the Androst-16-en-3-ol Framework
    Koch, V.; Meschkov, A.; Feuerstein, W.; Pfeifer, J.; Fuhr, O.; Nieger, M.; Schepers, U.; Bräse, S.
    2019. Inorganic chemistry, 58 (23), 15917–15926. doi:10.1021/acs.inorgchem.9b02402
  5. Zirconyl Hydrogenphosphate Nanocontainers for Flexible Transport and Release of Lipophilic Cytostatics, Insecticides, and Antibiotics
    Rein, V.; Meschkov, A.; Hagens, K.; Redinger, N.; Schepers, U.; Mehlhorn, H.; Schaible, U. E.; Feldmann, C.
    2019. Advanced functional materials, 29 (28), Art.Nr.: 1900543. doi:10.1002/adfm.201900543
  6. New Polyfluorinated Cyanine Dyes for Selective NIR Staining of Mitochondria
    Braun, A. B.; Wehl, I.; Kölmel, D. K.; Schepers, U.; Bräse, S.
    2019. Chemistry - a European journal, 25 (34), 7998–8002. doi:10.1002/chem.201900412
  7. On the design of new europium heteroaromatic carboxylates for OLED application
    Koshelev, D. S.; Chikineva, T. Y.; Khudoleeva, V. Y.; Medvedko, A. V.; Vashchenko, A. A.; Goloveshkin, A. S.; Tsymbarenko, D. M.; Averin, A. A.; Meschkov, A.; Schepers, U.; Vatsadze, S. Z.; Utochnikova, V. V.
    2019. Dyes and pigments, 170, 107604. doi:10.1016/j.dyepig.2019.107604
  8. Controlling the Uptake of Diarylethene‐Based Cell‐Penetrating Peptides into Cells Using Light
    Schober, T.; Wehl, I.; Afonin, S.; Babii, O.; Iampolska, A.; Schepers, U.; Komarov, I. V.; Ulrich, A. S.
    2019. ChemPhotoChem, 3 (6), 384–391. doi:10.1002/cptc.201900019
  9. 3-D geometry and irregular connectivity dictate neuronal firing in frequency domain and synchronization
    Ren, T.; Grosshäuser, B.; Sridhar, K.; Nieland, T. J. F.; Tocchio, A.; Schepers, U.; Demirci, U.
    2019. Biomaterials, 197, 171–181. doi:10.1016/j.biomaterials.2019.01.017
  10. Fluorescent Inorganic-Organic Hybrid Nanoparticles
    Neumeier, B. L.; Khorenko, M.; Alves, F.; Goldmann, O.; Napp, J.; Schepers, U.; Reichardt, H. M.; Feldmann, C.
    2019. ChemNanoMat, 5 (1), 24–45. doi:10.1002/cnma.201800310
  11. Brightly luminescent lanthanide pyrazolecarboxylates: Synthesis, luminescent properties and influence of ligand isomerism
    Utochnikova, V. V.; Abramovich, M. S.; Latipov, E. V.; Dalinger, A. I.; Goloveshkin, A. S.; Vashchenko, A. A.; Kalyakina, A. S.; Vatsadze, S. Z.; Schepers, U.; Bräse, S.; Kuzmina, N. P.
    2019. Journal of luminescence, 205, 429–439. doi:10.1016/j.jlumin.2018.09.027
2018
  1. Lanthanide pyrazolecarboxylates for OLEDs and bioimaging
    Utochnikova, V. V.; Latipov, E. V.; Dalinger, A. I.; Nelyubina, Y. V.; Vashchenko, A. A.; Hoffmann, M.; Kalyakina, A. S.; Vatsadze, S. Z.; Schepers, U.; Bräse, S.; Kuzmina, N. P.
    2018. Journal of luminescence, 202, 38–46. doi:10.1016/j.jlumin.2018.05.022
  2. Fluorescent Sulfonate-Based Inorganic–Organic Hybrid Nanoparticles for Staining and Imaging
    Poß, M.; Zittel, E.; Meschkov, A.; Schepers, U.; Feldmann, C.
    2018. Bioconjugate chemistry, 29 (8), 2818–2828. doi:10.1021/acs.bioconjchem.8b00423
  3. Combinatorial Synthesis of Peptoid Arrays via Laser-Based Stacking of Multiple Polymer Nanolayers
    Mattes, D. S.; Streit, B.; Bhandari, D. R.; Greifenstein, J.; Foertsch, T. C.; Münch, S. W.; Ridder, B.; v. Bojničić-Kninski, C.; Nesterov-Mueller, A.; Spengler, B.; Schepers, U.; Bräse, S.; Loeffler, F. F.; Breitling, F.
    2018. Macromolecular rapid communications, 40 (6), Art.Nr.: 1800533. doi:10.1002/marc.201800533
  4. Gd[AlPCS] Nanoagent Generating O for Photodynamic Therapy
    Poß, M.; Zittel, E.; Seidl, C.; Meschkov, A.; Muñoz, L.; Schepers, U.; Feldmann, C.
    2018. Advanced functional materials, 28 (32), 1801074. doi:10.1002/adfm.201801074
  5. A new structure–activity relationship for cyanine dyes to improve photostability and fluorescence properties for live cell imaging
    Schwechheimer, C.; Rönicke, F.; Schepers, U.; Wagenknecht, H.-A.
    2018. Chemical science, 9, 6557–6563. doi:10.1039/C8SC01574K
  6. Click chemistry-mediated biotinylation reveals a function for the protease BACE1 in modulating the neuronal surface glycoproteome
    Herber, J.; Njavro, J.; Feederle, R.; Schepers, U.; Müller, U.; Bräse, S.; Müller, S.; Lichtenthaler, S. F.
    2018. Molecular & cellular proteomics, 17 (8), 1487–1501. doi:10.1074/mcp.RA118.000608
  7. Remarkable high efficiency of red emitters using Eu(III) ternary complexes
    Kalyakina, A. S.; Utochnikova, V. V.; Zimmer, M.; Dietrich, F.; Kaczmarek, A. M.; Van Deun, R.; Vashchenko, A. A.; Goloveshkin, A. S.; Nieger, M.; Gerhards, M.; Schepers, U.; Bräse, S.
    2018. Chemical communications, 54 (41), 5221–5224. doi:10.1039/C8CC02930J
  8. “siRNA traffic lights”: arabino-configured 2′-anchors for fluorescent dyes are key for dual color readout in cell imaging
    Steinmeyer, J.; Walter, H.-K.; Bichelberger, M. A.; Schneider, V.; Kubař, T.; Rönicke, F.; Olshausen, B.; Nienhaus, K.; Nienhaus, G. U.; Schepers, U.; Elstner, M.; Wagenknecht, H.-A.
    2018. Organic & biomolecular chemistry, 16 (20), 3726–3731. doi:10.1039/C8OB00417J
  9. vasQchip : A Novel Microfluidic, Artificial Blood Vessel Scaffold for Vascularized 3D Tissues
    Kappings, V.; Grün, C.; Ivannikov, D.; Hebeiss, I.; Kattge, S.; Wendland, I.; Rapp, B. E.; Hettel, M.; Deutschmann, O.; Schepers, U.
    2018. Advanced Materials Technologies, 3 (4), Art.Nr. 1700246. doi:10.1002/admt.201700246
  10. Durchblutete Organe auf dem Chip. Entwicklung eines vaskularisierten Organ-on-Chip System
    Grün, C.; Pfister, R.; Haase, S.; Schepers, U.
    2018. GIT, (2), 2–4
  11. Reporting pH-sensitive drug release via unpaired spin fluorescence silencing
    Eing, M.; Olshausen, B.; Fairfull-Smith, K. E.; Schepers, U.; Barner-Kowollik, C.; Blinco, J. P.
    2018. Polymer chemistry, 9 (4), 499–505. doi:10.1039/C7PY01942D
  12. Fish-Microarray: A Miniaturized Platform for Single-Embryo High-Throughput Screenings
    Popova, A. A.; Marcato, D.; Peravali, R.; Wehl, I.; Schepers, U.; Levkin, P. A.
    2018. Advanced functional materials, 28 (3), 1703486. doi:10.1002/adfm.201703486
2017
  1. An optimized version of the Secretome Protein Enrichment with Click Sugars (SPECS) method leads to enhanced coverage of the secretome
    Serdaroglu, A.; Müller, S. A.; Schepers, U.; Bräse, S.; Weichert, W.; Lichtenthaler, S. F.; Kuhn, P.-H.
    2017. Proteomics, 17 (5), Art.Nr. 1600423. doi:10.1002/pmic.201600423
  2. Lanthanide Fluorobenzoates as Bio-Probes : a Quest for the Optimal Ligand Fluorination Degree
    Kalyakina, A. S.; Utochnikova, V. V.; Bushmarinov, I. S.; Le-Deygen, I. M.; Volz, D.; Weis, P.; Schepers, U.; Kuzmina, N. P.; Bräse, S.
    2017. Chemistry - a European journal, 23 (59), 14944–14953. doi:10.1002/chem.201703543
  3. Microemulsion-made gadolinium carbonate hollow nanospheres showing magnetothermal heating and drug release
    Jung-König, J.; Sanhaji, M.; Popescu, R.; Seidl, C.; Zittel, E.; Schepers, U.; Gerthsen, D.; Hilger, I.; Feldmann, C.
    2017. Nanoscale, 9 (24), 8362–8372. doi:10.1039/c7nr01784g
  4. Synthesis of Wavelength-Shifting Fluorescent DNA and RNA with Two Photostable Cyanine-Styryl Dyes as the Base Surrogate Pair
    Steinmeyer, J.; Rönicke, F.; Schepers, U.; Wagenknecht, H.-A.
    2017. ChemistryOpen, 6 (4), 514–518. doi:10.1002/open.201700059
  5. Europium 2-benzofuranoate : Synthesis and use for bioimaging
    Utochnikova, V. V.; Koshelev, D. S.; Medvedko, A. V.; Kalyakina, A. S. ..; Bushmarinov, I. S.; Grishko, A. Y.; Schepers, U.; Bräse, S.; Vatsadze, S. Z.
    2017. Optical materials, 74, 191–196. doi:10.1016/j.optmat.2017.05.038
  6. Surface modified EuₓLa₁₋ₓF₃ nanoparticles as luminescent biomarkers : Still plenty of room at the bottom
    Khudoleeva, V.; Utochnikova, V. V.; Kalyakina, A. S.; Deygen, I. M.; Shiryaev, A. A.; Marciniak, Ł.; Lebedev, V. A.; Roslyakov, I. V.; Garshev, A. V.; Lepnev, L. S.; Schepers, U.; Bräse, S.; Kuzmina, N. P.
    2017. Dyes and pigments, 143, 348–355. doi:10.1016/j.dyepig.2017.04.058
  7. Double-Strand DNA Breaks Induced by Paracyclophane Gold(I) Complexes
    Bestgen, S.; Seidl, C.; Wiesner, T.; Zimmer, A.; Falk, M.; Köberle, B.; Austeri, M.; Paradies, J.; Bräse, S.; Schepers, U.; Roesky, P. W.
    2017. Chemistry - a European journal, 23 (26), 6315–6322. doi:10.1002/chem.201605237
  8. A postsynthetically 2’-“clickable” uridine with arabino configuration and its application for fluorescent labeling and imaging of DNA
    Walter, H.-K.; Olshausen, B.; Schepers, U.; Wagenknecht, H.-A.
    2017. Beilstein journal of organic chemistry, 13, 127–137. doi:10.3762/bjoc.13.16
2016
  1. Novel Prodrug of Doxorubicin Modified by Stearoylspermine Encapsulated into PEG-Chitosan-Stabilized Liposomes
    Deygen, I. M.; Seidl, C.; Kölmel, D. K.; Bednarek, C.; Heissler, S.; Kudryashova, E. V.; Bräse, S.; Schepers, U.
    2016. Langmuir, 32 (42), 10861–10869. doi:10.1021/acs.langmuir.6b01023
  2. A Modular Class of Fluorescent Difluoroboranes: Synthesis, Structure, Optical Properties, Theoretical Calculations and Applications for Biological Imaging
    Bachollet, S. P. J. T.; Volz, D.; Fiser, B.; Münch, S.; Rönicke, F.; Carrillo, J.; Adams, H.; Schepers, U.; Gómez-Bengoa, E.; Bräse, S.; Harrity, J. P. A.
    2016. Chemistry - a European journal, 22 (35), 12430–12438. doi:10.1002/chem.201601915
  3. Chemical Synthesis of Glycosaminoglycans
    Mende, M.; Bednarek, C.; Wawryszyn, M.; Sauter, P.; Biskup, M. B.; Schepers, U.; Bräse, S.
    2016. Chemical reviews, 116 (14), 8193–8255. doi:10.1021/acs.chemrev.6b00010
  4. Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function
    Kuhn, P.-H.; Colombo, A. V.; Schusser, B.; Dreymueller, D.; Wetzel, S.; Schepers, U.; Herber, J.; Ludwig, A.; Kremmer, E.; Montag, D.; Müller, U.; Schweizer, M.; Saftig, P.; Bräses, S.; Lichtenthaler, S. F.
    2016. eLife, 5 (JANUARY2016), e12748. doi:10.7554/eLife.12748
  5. Tin Tungstate Nanoparticles: A Photosensitizer for Photodynamic Tumor Therapy
    Seidl, C.; Ungelenk, J.; Zittel, E.; Bergfeldt, T.; Sleeman, J. P.; Schepers, U.; Feldmann, C.
    2016. ACS nano, 10 (3), 3149–3157. doi:10.1021/acsnano.5b03060
  6. Leukocyte responses to immobilized patterns of CXCL8
    Girrbach, M.; Rink, I.; Ladnorg, T.; Azucena, C.; Heissler, S.; Haraszti, T.; Schepers, U.; Schmitz, K.
    2016. Colloids and surfaces / B, 142, 385–391. doi:10.1016/j.colsurfb.2016.03.004
  7. Polarity Sensitive Bioorthogonally Applicable Far-Red Emitting Labels for Postsynthetic Nucleic Acid Labeling by Copper-Catalyzed and Copper-Free Cycloaddition
    Eördögh, A.; Steinmeyer, J.; Peewasan, K.; Kele, P.; Schepers, U.; Wagenknecht, H.-A.
    2016. Bioconjugate Chemistry, 27 (2), 457–464. doi:10.1021/acs.bioconjchem.5b00557
2015
  1. Bioprinting: Organe aus dem Drucker?
    Schepers, U.
    2015. Nachrichten aus der Chemie, 63 (3), 309–314. doi:10.1002/nadc.201590093
  2. Gallic acid induces mitotic catastrophe and inhibits centrosomal clustering in HeLa cells
    Tan, S.; Guan, X.; Grün, C.; Zhou, Z.; Schepers, U.; Nick, P.
    2015. Toxicology in vitro, 30 (1, Part B), 506–513. doi:10.1016/j.tiv.2015.09.011
  3. Highly luminescent, water-soluble lanthanide fluorobenzonates : Syntheses, structures and photophysics, Part I : Lanthanide pentafluorobenzoates
    Kalyakina, A. S.; Utochnikova, V. V.; Bushmarinov, I. S.; Ananyev, I. V.; Eremenko, I. L.; Volz, D.; Rönicke, F.; Schepers, U.; Van Deun, R.; Trigub, A. L.; Zubavichus, Y. V.; Kuzmina, N. P.; Bräse, S.
    2015. Chemistry - a European journal, 21 (49), 17921–17932. doi:10.1002/chem.201501816
  4. Synthesis of new diketopiperazines, thiolation to thiodiketopiperazines, and examination of ateir ROS-generating properties
    Zhong, S.; Wandler, A. E. E.; Schepers, U.; Nieger, M.; Bräse, S.
    2015. European Journal of Organic Chemistry, (31), 6858–6871. doi:10.1002/ejoc.201500900
  5. Secretome analysis identifies novel signal peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple golgi glycosylation pathways
    Kuhn, P. H.; Voss, M.; Haug-Kröper, M.; Schröder, B.; Schepers, U.; Bräse, S.; Haass, C.; Lichtenthaler, S. F.; Fluhrer, R.
    2015. Molecular & cellular proteomics, 14 (6), 1584–1598. doi:10.1074/mcp.M115.048298
  6. Photophysical properties and synthesis of new dye-cyclooctyne conjugates for multicolor and advanced microscopy
    Hörner, A.; Hagendorn, T.; Schepers, U.; Bräse, S.
    2015. Bioconjugate chemistry, 26 (4), 718–724. doi:10.1021/acs.bioconjchem.5b00059
  7. Functionalized triazolopeptoids-a novel class for mitochondrial targeted delivery
    Althuon, D.; Rönicke, F.; Fürniss, D.; Quan, J.; Wellhöfer, I.; Jung, N.; Schepers, U.; Bräse, S.
    2015. Organic & biomolecular chemistry, 13, 4226–4230. doi:10.1039/C5OB00250H
2014
  1. Bright Coppertunities: Multinuclear CuI Complexes with N-P Ligands and Their Applications
    Wallesch, M.; Volz, D.; Zink, D. M.; Schepers, U.; Nieger, M.; Baumann, T.; Bräse, S.
    2014. Chemistry - a European journal, 20 (22), 6578–6590. doi:10.1002/chem.201402060
  2. Switchable fluorescence by click reaction of a novel azidocarbazole dye
    Hörner, A.; Volz, D.; Hagendorn, T.; Furniss, D.; Greb, L.; Ronicke, F.; Nieger, M.; Schepers, U.; Bräse, S.
    2014. RSC Advances, 4 (23), 11528–11534. doi:10.1039/C3RA47964A
  3. In vitro fluorescence and phototoxicity of β-SnWO₄ nanoparticles
    Ungelenk, J.; Seidl, C.; Zittel, E.; Roming, S.; Schepers, U.; Feldmann, C.
    2014. Chemical communications, 50, 6600–6603. doi:10.1039/C4CC00308J
  4. Cytotoxicity and NMR studies of platinum complexes with cyclooctadiene ligands
    Enders, M.; Görling, B.; Braun, A. B.; Seltenreich, J. E.; Reichenbach, L. F.; Rissanen, K.; Nieger, M.; Luy, B.; Schepers, U.; Bräse, S.
    2014. Organometallics, 33, 4027–4034. doi:10.1021/om500540x
  5. Cell-penetrating peptoids: introduction of novel cationic side chains
    Kölmel, D. K.; Hörner, A.; Rönicke, F.; Nieger, M.; Schepers, U.; Bräse, S.
    2014. European journal of medicinal chemistry, 79, 231–243. doi:10.1016/j.ejmech.2014.03.078
2013
  1. Luminescent cell-penetrating pentadecanuclear lanthanide clusters
    Thielemann, D. T.; Wagner, A. T.; Rösch, E.; Kölmel, D. K.; Heck, J. G.; Rudat, B.; Neumaier, M.; Feldmann, C.; Schepers, U.; Bräse, S.; Roesky, P. W.
    2013. Journal of the American Chemical Society, 135 (20), 7454–7457. doi:10.1021/ja403539t
  2. Amphiphilic peptoid transporters - synthesis and evaluation
    Vollrath, S. B. L.; Fürniss, D.; Schepers, U.; Bräse, S.
    2013. Organic and Biomolecular Chemistry, 11, 8197–8201. doi:10.1039/C3OB41139G
  3. Peptoid-based rare-earth (group 3 and lanthanide) transporters
    Kölmel, D. K.; Rudat, B.; Schepers, U.; Bräse, S.
    2013. European Journal of Organic Chemistry, (14), 2761–2765. doi:10.1002/ejoc.201300219
  4. Rhodamine F: a novel class of fluorous ponytailed dyes for bioconjugation
    Kölmel, D. K.; Rudat, B.; Braun, D. M.; Bednarek, C.; Schepers, U.; Bräse, S.
    2013. Organic and Biomolecular Chemistry, 11, 3954–3962. doi:10.1039/C3OB40267C
  5. Peptoids and polyamines going sweet: Modular synthesis of glycosylated peotoids and polyamines using click chemistry
    Fürniss, D.; Mack, T.; Hahn, F.; Vollrath, S. B. L.; Koroniak, K.; Schepers, U.; Bräse, S.
    2013. Beilstein Journal of Organic Chemistry, 9, 56–63. doi:10.3762/bjoc.9.7
  6. Structural Characterization of a Peptoid with Lysine-like Side Chains and Biological Activity using NMR and Computational Methods
    Sternberg, U.; Birtalan, E.; Jakovkin, I.; Luy, B.; Schepers, U.; Bräse, S.; Muhle-Goll, C.
    2013. Organic and Biomolecular Chemistry, 11 (4), 640–647. doi:10.1039/c2ob27039k
2012
  1. Cell Penetrating Peptoids (CPPos): Synthesis of a Small Combinatorial Library by Using IRORI MiniKans
    Kölmel, D. K.; Fürniss, D.; Susanto, S.; Lauer, A.; Grabher, C.; Bräse, S.; Schepers, U.
    2012. Pharmaceuticals, 5 (12), 1265–1281. doi:10.3390/ph5121265
  2. Synthesis of Functionalized Glutamine- and Asparagine-Type Peptoids : Scope and Limitations
    Cardenal, C.; Vollrath, S. B. L.; Schepers, U.; Bräse, S.
    2012. Helvetica chimica acta, 95 (11), 2237–2248. doi:10.1002/hlca.201200451
  3. Killing double bonds softly: the reduction of polymer-bound alkenes
    Fürniss, D.; Schepers, U.; Bräse, S.
    2012. RSC Advances, 2 (30), 11273–11278. doi:10.1039/c2ra22189f
  4. The plakotenins: biomimetic Diels-Alder reactions, total synthesis, structural investigations, and chemical biology
    Bourcet, E.; Kaufmann, L.; Arzt, S.; Bihlmeier, A.; Klopper, W.; Schepers, U.; Bräse, S.
    2012. Chemistry - a European journal, 18 (47), 15004–15020. doi:10.1002/chem.201201585
  5. Secretome Protein Enrichment with Click Sugars Identifies Physiological Substrates of the Alzheimer Protease BACE1 in Primary Neurons
    Kuhn, P. H.; Koroniak, K.; Hogl, S.; Colombo, A.; Zeitschel, U.; Willem, M.; Volbracht, C.; Schepers, U.; Imhof, A.; Hoffmeister, A.; Haass, C.; Roßner, S.; Bräse, S.; Lichtenthaler, S. F.
    2012. The EMBO journal, 31 (14), 3157–3168. doi:10.1038/emboj.2012.173
  6. Interkingdom Signaling: Integration, Conformation, and Orientation of N-Acyl-L-Homoserine Lactones in Supported Lipid Bilayers
    Barth, C.; Jakubczyk, D.; Kubas, A.; Anastassacos, F.; Brenner-Weiss, G.; Fink, K.; Schepers, U.; Bräse, S.; Koelsch, P.
    2012. Langmuir, 28 (22), 8456–8462. doi:10.1021/la301241s
  7. Deuterium labelled N-acyl-L-homoserine lactones (AHLs) - Inter-kingdom signalling molecules - synthesis, structural studies, interaction with model lipid membranes
    Jakubczyk, D.; Barth, C.; Kubas, A.; Anastassacos, F.; Koelsch, P.; Fink, K.; Schepers, U.; Brenner-Weiß, G.; Bräse, S.
    2012. Analytical and bioanalytical chemistry, 403 (2), 473–482. doi:10.1007/s00216-012-5839-4
  8. Novel three-dimensional Boyden chamber system for studying transendothelial transport
    Hebeiss, I.; Truckenmüller, R.; Giselbrecht, S.; Schepers, U.
    2012. Lab on a Chip, 12, 829–834. doi:10.1039/c2lc20733h
2011
  1. Photophysical properties of fluorescently-labeled peptoids
    Rudat, B.; Birtalan, E.; Vollrath, S. B. L.; Fritz, D.; Kölmel, D. K.; Nieger, M.; Schepers, U.; Müllen, K.; Eisler, H.-J.; Lemmer, U.; Bräse, S.
    2011. European Journal of Medicinal Chemistry, 46 (9), 4457–4465. doi:10.1016/j.ejmech.2011.07.020
  2. Bioconjugation via azide-Staudinger ligation: an overview
    Schilling, C. I.; Jung, N.; Biskup, M. B.; Schepers, U.; Bräse, S.
    2011. Chemical Society Reviews, 40 (9), 4840–4871. doi:10.1039/C0CS00123F
  3. Investigating rhodamine B-labelled peptoids: Scopes and Limitations of its applications
    Birtalan, E.; Rudat, B.; Kölmel, D. K.; Fritz, D.; Vollrath, S. B. L.; Schepers, U.; Bräse, S.
    2011. Peptide science, 96 (5), 694–701. doi:10.1002/bip.21617
  4. Goldnanopartikel als Radiosensitizer in menschlichen Tumorzellen bei der Bestrahlung mit 50 kV und 6 MV Photonen
    Burger, N.; Veldwijk, M. R.; Bednarek, C.; Schepers, U.; Herskind, C.; Wenz, F.
    2011. Strahlentherapie und Onkologie / Supplement, 17. Jahreskongress der Deutschen Gesellschaft für Radioonkologie (DEGRO 2011), Wiesbaden, 2.-5.Juni 2011, (Abstract P189), 124 (1), 124
2007
  1. Solid-phase synthesis, bioconjugation, and toxicology of novel cationic oligopeptoids for cellular drug delivery
    Schröder, T.; Schmitz, K.; Niemeier, N.; Balaban, T. S.; Krug, H. F.; Schepers, U.; Bräse, S.
    2007. Bioconjugate Chemistry, 18, 342–54. doi:10.1021/bc0602073