Our research is at the interface of chemical biology, materials science, and 3D tissue engineering and health technologies. It focuses on three key areas: Organ-specific drug delivery, the autonomous reconstruction of organoids and 3D tissues and the AI-driven development of innovative biomaterials for the 3D bioprinting of entire organs and tissues. Precise organ-specific drug delivery is only possible if realistic test systems such as organoids or artificially reconstructed 3D tissues on so-called organs-on-a-chip are available. We are therefore developing autonomous and AI-controlled processes for the automated production of these biological models. At the same time, we are optimizing the material properties and manufacturing processes of high-precision biomaterials in self-driving labs using artificial intelligence in order to create functional, customizable inks for 3D bioprinting and thus enable new approaches in regenerative medicine and drug research. A particular focus is on biocompatible materials for the 3D printing of individualized heart valves, corneas and other functional tissue structures for organ-on-chip systems such as the vascularization of brain, heart and intestine tissues. Our research ranges from high-throughput experiments to identify optimal material properties through to validation in animal models. Our research thus makes an important contribution to the further development of personalized therapeutic approaches.

Find out more at the Chemical Biology of Precision Biomaterials website.

Organ Targeted Drug Delivery Group
From organ-targeted drug delivery to autonomous high-throughput biomaterials development for 3D tissue printing and organoids reconstruction in personalized medicine.