Institut für Funktionelle Grenzflächen (IFG)

Surface anchored metal-organic frameworks as stimulus responsive antifouling coatings

  • Autor:

    Arpa Sancet, M. / Hanke, M. / Wang, Z. / Bauer, S. / Azucena, C. / Arslan, H. / Heinle, M. / Gliemann, H. / Wöll, C. / Rosenhahn, A. (2013)

  • Quelle:

    Biointerphases (2013), 8, 29, doi:10.1186/1559-4106-8-29

  • Datum: 2013
  • Arpa Sancet, M. / Hanke, M. / Wang, Z. / Bauer, S. / Azucena, C. / Arslan, H. / Heinle, M. / Gliemann, H. / Wöll, C. / Rosenhahn, A. (2013): „Surface anchored metal-organic frameworks as stimulus responsive antifouling coatings“. In: Biointerphases 8 (2013)

Abstract

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Surface-anchored, crystalline and oriented metal organic frameworks (SURMOFs) have huge potential for biological applications due to their well-defined and highly-porous structure. In this work we describe a MOF-based, fully autonomous system, which combines sensing, a specific response, and the release of an antimicrobial agent. The Cu-containing SURMOF, Cu-SURMOF 2, is stable in artificial seawater and shows stimulus-responsive anti-fouling properties against marine bacteria. When Cobetia marina adheres on the SURMOF, the framework’s response is lethal to the adhering microorganism.

A thorough analysis reveals that this response is induced by agents secreted from the microbes after adhesion to the substrate, and includes a release of Cu ions resulting from a degradation of the SURMOF. The stimulus-responsive antifouling effect of Cu-SURMOF 2 demonstrates the first application of Cu-SURMOF 2 as autonomous system with great potential for further microbiological and cell culture applications.