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Dr. Cornelia Lee-Thedieck
Dr. Cornelia Lee-Thedieck

 

+49-721-608-2-3588
+49-721-608-2-3478
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Junior Research Group Lee-Thedieck: Stem Cell-Material Interactions

Stammzell


Hematopoietic stem cells (HSCs) give rise to all types of blood cells. Up to now, they cannot be expanded in vitro without loosing their stem cell character. In the body they are maintained in specialized microenvironments, so-called stem cell niches.

The aim of our group is to develop and test biomaterials, which mimic the HSC niche in regard to its specific ligands, micro- and nanostructure, dimensionality as well as mechanical properties.

We study the interaction of HSCs with these biomimetic materials in order understand how the physical and mechanical properties of the environment influence HSCs. The final goal of these studies is to create an artificial stem cell niche for the in vitro proliferation of HSCs.

 

News

2.10.2017

Hamidreza Pirmahboub begins his PhD in our group.

1.10.2017

Our BMBF project " Biomimetic Nanostructure materials for cultivation hematopoetic stem cells" turns successful to the scond promotion phase.

6.9.2017

Cornelia Lee-Theedieck receives ERC Starting Grant. The European Research Council decided to fund her project “bloodANDbone” with EUR 1.5 million for five years. http://www.kit.edu/kit/english/pi_2017_125_bone-marrow-models-to-study-blood-and-musculoskeletal-disorders.php

6.9.2017

Our new article "Bioinstructive Coatings for Hematopoetic Stem Cell Expansion Based on Chemical Vapor Deposition Copolymerization" is published in the Jorrnal Biomacromolecules. http://pubs.acs.org/doi/abs/10.1021/acs.biomac.7b00743

14.8.2017

Marvin Subarew starts his master thesis in or group.

1.6.17

Anita Ludwig-Husemann begins her PhD in our group.

22.5.2017

Our article "3D models of the hematopoetic stem cell niche under steady-state and active conditions" appearsin Scientific Reports
http:// www.nature.com/articles/s41598-017-04808-0

3.4.2017

Our article "Significance of Nanopatterned and Clustered DLL1 for Hematopoietic Stem Cell Proliferation" appears online at Advanced Functional Materials: 

http://onlinelibrary.wiley.com/doi/10.1002/adfm.201606495/full

 

14.2.2017

Our manuscript "Significance of Nanopatterned and Clustered DLL1 for Hematopoietic Stem Cell Proliferation" is accepted at Advanced Functional Materials!

 

 

15.10.2016

                                                                                                                                    Sabrina Zippel begins her bachelor thesis in our group.                                                                                                                                                    

01.10.2016

                                                                                                                                                        Domenic Kratzer gets a poster prize of Jahrestagung der Deutschen Gesellschaft für Biomaterialien.

 

01.10.2016

                                                                                                                                                        Elena Kemmling starts her bachelor thesis in our group.

 

01.09.2016

                                                                                                                                                        Lena Uebele starts her master thesis in or group.

 

29.03.2016

                                                                                                                                                        Sophie Riedel and Martina Deimling start their bachelor thesis in our group.

 

22.03.2016

                                                                                                                                                        Our paper "Direct Mapping of RAFT Controlled Macromolecular Growth on Surfaces via Single Molecule Force Spectroscopy" is accepted in ACS Macro Letters!

Link:http://pubsdc3.acs.org/doi/full/10.1021/acsmacrolett.6b00106

 

01.01.2016

                                                                                                                                                 Domenic Kratzer begins as a postdoc in our group.

 

05.10.2015

                                                                                                                                                         Katharina Junges starts her master thesis in our group.


01.10.2105

                                                                                                                                                         Julia Hümmer beginns her PhD in a cooperation project with the department of chemistry of oxydic and organic interfaces.

 

01.09.2015

                                                                                                                                               Elena Kemmling does an internship ('practical semester') in our lab.


15.09.2014


Annamarija Raic starts her PhD in our group.

 

17.07.2014


The Review „Biophysical Regulation of Hematopoietic Stem Cells“ is published in the journal Biomaterials Science.

 

01.05.2014


Thomas Tischer joins our group as a postdoc.

 

04.04.2014


The Baden-Württemberg Foundation funds the project ‘LektiSwitch”, which we will carry out together with our cooperation partners from the University of Ulm.