Hematopoietic stem cells (HSCs) give rise to all types of blood cells. Up to now, they cannot be expanded in vitro without loosing their stem cell character. In the body they are maintained in specialized microenvironments, so-called stem cell niches.
The aim of our group is to develop and test biomaterials, which mimic the HSC niche in regard to its specific ligands, micro- and nanostructure, dimensionality as well as mechanical properties.
We study the interaction of HSCs with these biomimetic materials in order understand how the physical and mechanical properties of the environment influence HSCs. The final goal of these studies is to create an artificial stem cell niche for the in vitro proliferation of HSCs.
Hamidreza Pirmahboub begins his PhD in our group.
Our BMBF project " Biomimetic Nanostructure materials for cultivation hematopoetic stem cells" turns successful to the scond promotion phase.
Cornelia Lee-Theedieck receives ERC Starting Grant. The European Research Council decided to fund her project “bloodANDbone” with EUR 1.5 million for five years. http://www.kit.edu/kit/english/pi_2017_125_bone-marrow-models-to-study-blood-and-musculoskeletal-disorders.php
Our new article "Bioinstructive Coatings for Hematopoetic Stem Cell Expansion Based on Chemical Vapor Deposition Copolymerization" is published in the Jorrnal Biomacromolecules. http://pubs.acs.org/doi/abs/10.1021/acs.biomac.7b00743
Marvin Subarew starts his master thesis in or group.1.6.17
Anita Ludwig-Husemann begins her PhD in our group.
Our article "3D models of the hematopoetic stem cell niche under steady-state and active conditions" appearsin Scientific Reports
Our article "Significance of Nanopatterned and Clustered DLL1 for Hematopoietic Stem Cell Proliferation" appears online at Advanced Functional Materials:
Our manuscript "Significance of Nanopatterned and Clustered DLL1 for Hematopoietic Stem Cell Proliferation" is accepted at Advanced Functional Materials!
Sabrina Zippel begins her bachelor thesis in our group.
Domenic Kratzer gets a poster prize of Jahrestagung der Deutschen Gesellschaft für Biomaterialien.
Elena Kemmling starts her bachelor thesis in our group.
Lena Uebele starts her master thesis in or group.
Sophie Riedel and Martina Deimling start their bachelor thesis in our group.
Our paper "Direct Mapping of RAFT Controlled Macromolecular Growth on Surfaces via Single Molecule Force Spectroscopy" is accepted in ACS Macro Letters!
Domenic Kratzer begins as a postdoc in our group.
Katharina Junges starts her master thesis in our group.
Julia Hümmer beginns her PhD in a cooperation project with the department of chemistry of oxydic and organic interfaces.
Elena Kemmling does an internship ('practical semester') in our lab.
Annamarija Raic starts her PhD in our group.
The Review „Biophysical Regulation of Hematopoietic Stem Cells“ is published in the journal Biomaterials Science.
Thomas Tischer joins our group as a postdoc.
The Baden-Württemberg Foundation funds the project ‘LektiSwitch”, which we will carry out together with our cooperation partners from the University of Ulm.