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2007

Publikationen vor 2009

2009

  • Hahn F, Schepers U (2009) Thieme Chemistry Journal Awardees - Where are They Now? A Convenient Route for Introduction of Lipophilic Side Chains in Polyamine Backbones by Solid-Phase Synthesis. Synlett 2755-2760.
  • Bauer R, Voelzmann A, Breiden B, Schepers U, Farwanah H, Hahn I, Eckardt F, Sandhoff K, Hoch M (2009) Schlank, a member of the ceramide synthase family controls growth and body fat in Drosophila. EMBO J. 28: 3706-3716.
 

2008

  • Hahn F, Schmitz K, Balaban TS, Bräse S, Schepers U (2008) Conjugation of spermine facilitates cellular uptake and enhances antitumor and antibiotic properties of highly lipophilic porphyrins. ChemMedChem 3: 1185-1188.
  • Hahn F, Schepers U (2008) Versatile procedure for asymmetric and orthogonal protection of symmetric polyamines and its advantages for solid phase synthesis. J. Comb. Chem. 10: 267-273.
  • Hahn F, Müllen K, Schepers U (2008) 2-Iminothiolane as a Useful Coupling Reagent for Polyamine Solid-Phase Synthesis. Synlett 2785-2790.
 

2007

  • Schulze H, Schepers U, Sandhoff K (2007) Overexpression and mass spectrometry analysis of mature human acid ceramidase. Biol. Chem. 388: 1333-1343.
  • Schröder T, Schmitz K, Niemeier N, Balaban TS, Krug HF, Schepers U, Bräse S (2007) Solid-phase synthesis, bioconjugation, and toxicology of novel cationic oligopeptoids for cellular drug delivery. Bioconjug. Chem. 18: 342-354.
  • Hahn F, Schepers U (2007) Solid phase chemistry for the directed synthesis of biologically active polyamine analogs, derivatives, and conjugates. Top. Curr. Chem. 278: 135-208.
 

2005

  • Diallo M, Schmitz K, Schepers U (2005) RNA interference: RNAid for future therapeutics. Humana Press, Totowa, NY.
 

2004

  • Walter J, Prager K, Diallo M, Wahle T, Lütjohann D, Haass C, Sandhoff K, Schepers U, Tamboli I (2004) Glycosphingolipids regulate subcellular transport of the beta-amyloid procursor protein and the generation of amyloid beta-peptide. Neurobiol. Aging 25: S38-S38.
  • Schmitz K, Schepers U (2004) Polyamides as artificial transcription factors: novel tools for molecular medicine? Angew. Chem. Int. Ed. 43: 2472-2475.
  • Schepers U (2004) Die Wiederentdeckung der RNA. Nachr. Chem. 52: 302-305.
  • Schepers U (2004) RNA interference in practice, Wiley-VCH, Weinheim.
 

2003

  • Wendeler M, Lemm T, Weisgerber J, Hoernschemeyer J, Bartelsen O, Schepers U, Sandhoff K (2003) Expression of recombinant human GM2-activator protein in insect cells: purification and characterization by mass spectrometry. Protein Expr. Purif. 27: 259-266.
  • Schmitz K, Diallo M, Arenz C, Mundegar R, Sandhoff K, Schepers U (2003) Synthesis of a new carrier-system for transduction of siRNAs into cells for the local transient posttranscriptional gene silencing in mammals. Eur. J. Cell Biol. 82: 100-100.
  • Schmitz K, Arenz C, Diallo M, Cryns A, Hoffman S, Sandhoff K, Schepers U (2003) RNA interference: New approaches to study protein function in mammalian cells and organisms. Eur. J. Cell Biol. 82: 99-100.
  • Schepers U (2003) A stem cell molecular signature: Are there hallmark properties that are shared by all stem cells? Chembiochem 4: 716-720.
  • Diallo M, Schepers U (2003) RNA Interference: Everything What One Ever Wanted to Know About Silence! Bioforum Eur. 3: 143-145.
  • Diallo M, Arenz C, Schmitz K, Sandhoff K, Schepers U (2003) Stable post transcriptional gene silencing of glucosylceramicle-synthase by RNA interference in human cells. Eur. J. Cell Biol. 82: 98-98.
  • Diallo M, Arenz C, Schmitz K, Sandhoff K, Schepers U (2003) RNA interference: Analyzing the function of glycoproteins and glycosylating proteins in mammalian cells. Recognit. Carbohydr. Biol. Syst. B. 363: 173-190.
  • Diallo M, Arenz C, Schmitz K, Sandhoff K, Schepers U (2003) Long endogenous dsRNAs can induce complete gene silencing in mammalian cells and primary cultures. Oligonucleotides 13: 381-392.
  • Arenz C, Schepers U (2003) RNA interference: from an ancient mechanism to a state of the art therapeutic application? Naturwissenschaften 90: 345-359.
  • Arenz C, Cryns A, Diallo M, Sandhoff K, Schepers U (2003) Analysis of skin glycosphingolipid metabolism by RNA interference in transgenic mice. Eur. J. Cell Biol. 82: 97-97.
 

2001

  • Schepers U, Kolter T (2001) RNA interference: A new way to analyze protein function. Angew. Chem. Int. Ed. 40: 2437ff.
 

1992 - 2000

  • Schepers U, Lemm T, Herzog V, Sandhoff K (2000) Characterization of regulatory elements in the 5 '-flanking region of the GM2 activator gene. Biol. Chem. 381: 531-544.
  • Sakuraba H, Itoh K, Shimmoto M, Utsumi K, Kase R, Hashimoto Y, Ozawa T, Ohwada Y, Imataka G, Eguchi M, Furukawa T, Schepers U, Sandhoff K (1999) GM2 gangliosidosis AB variant - Clinical and biochemical studies of a Japanese patient. Neurology 52: 372-377.
  • Schepers U, Glombitza G, Lemm T, Hoffmann A, Chabas A, Ozand P, Sandhoff K (1996) Molecular analysis of a GM2-activator deficiency in two patients with GM2-gangliosidosis AB variant. Am. J. Hum. Genet. 59: 1048-1056.
  • Swallow DM, Islam I, Fox MF, Povey S, Klima H, Schepers U, Sandhoff K (1993) Regional localization of the gene coding for the GM2 activator protein (GM2A) to chromosome 5q32-33 and confirmation of the assignment of GM2AP to chromosome 3. Ann. Hum. Genet. 57: 187-193.